This study examined the effect of training spiritual therapy (14 steps spiritual therapy Dr. Taghizadeh)of in order to improve social adjustment and social acceptance were of women whit multiple sclerosis.  The study used a quasi-experimental design with pre-test post-test with control group. The study population included women with multiple sclerosis, was a member of the (MS)society and among them30 were selected by available. Sampling method and were randomly assigned to experimental and controle group(Eachgroup n=15). Then both groups was completed social adjustment (Bell) and social acceptance( Crown& Marlowe scale). Then spiritual therapy was taugth in12 two-houres sessions for experimental group. Then post-test was administered to both groups. The data were analized with Covariance.  The results showed that spirituality traning in group therapy improves social adjustment of women with multiple sclerosis (p<0/05)and social acceptance (p<0/05) has significant  According to the results , we can say that spiritual therapy improvement in social adjustment and social acceptance of women with MS has significant effect.