Objective: The aim of this study was comparing the health anxiety, Sensory processing sensitivity and harm avoidance in the nurses of Special sector and the public sector of hospital. Method: This research is a survey study of casual-comparative type. The population of this study included all nurses in the hospital of Ilam in 1394.by using available sampling method selected a sample  consisted of 120 nurses In two groups60 nurses in critical care units, 60 nurses in public care units. For data collections were used Health Anxiety Questionnaire Original short form (SHAI), Sensory Processing Sensitivity Questionnaire (1997) and Harm Avoidance Questionnaire (Taken from the Temperament and Character Inventory of Cloninger (TCI). Data obtained was analyzed through multivariate analysis of variance (MANOVA) and univariate. Results: The results indicate that there are significant differences between mean scores of health anxiety with harm avoidance and sensory processing sensitivity in level (0001/ > p) in critical care nurses and public sectors. The findings suggest that critical care nurses compared with nurses in the public sector more health anxiety experience. In the study sensory processing sensitivity variable and its subcomponent Results also showed that critical care nurses higher scores compared to nurses in public. Conclusion: According to the impact of health anxiety on the physical and mental aspects of nurses And the impact this has on the process of care provided by them As well as the differences in the various sectors, it would seem creating support systems in hospitals to provide better care by nurses And health promotion and increase the efficiency of the target society.