Current study aimed to investigate the relationship between dimension of perfectionism and interpersonal problems. To this purpose, among students of university of Tehran, a sample of 286 students, (154 females and 132 males) in 2016, completed Multidimensional Perfectionism Scale (TMPS), and Inventory of Interpersonal Problems (IIP-30). The Pearson correlation results demonstrated that intensity of interpersonal problems according to dimensions of perfectionism was significant at the level of (P<0/01) in each of the three dimensions, self-prescribed (0/31), other prescribed (0/31) and socially prescribed (0/39). Also hierarchy regression analysis showed that in men, among perfectionism dimensions, self and socially prescribed perfectionism if associated with other-oriented perfectionism, predicted interpersonal problems at the level of (P<0/05). In women, the socially prescribed perfectionism imposing severe expectations on them played an important role in relationship between other dimension of perfectionism and interpersonal problems (P<0/001). These findings are in line with new researches about adjustment of perfectionism. Also the importance of Gender differences in perfectionism and relation of its dimensions to interpersonal problems denoted by this study.