The Purpose of the present research was to examine the effectiveness of  Lego Therapy on social skills in children with Autism. The study population consisted of all boy children 6 to 12 years with Autism  from OMID-ASR Clinic 2015.  Sampling method was purposeful and 20 children with Autism selected (10 children experimental group and 10 control group). This is a quasi– experimental study with a pretest /post-test experimental and control group. In this study to experimental group Lego Therapy administered in 12 sessions and the control group not received training in this field. Instrument for the diagnosis of Autism disorder was DSM.5 and for social skills measured by Stone questionnaire were used. Results showed that Lego Therapy were effective in increasing social skills in children with Autism.Then, Lego Therapy is a useful intervention for increase of social skills with Autism.