The present study aimed to predict treatment adherence based on personality traits and motivation in patients with hypertension. The research method was descriptive-correlational. The study population consisted of individuals with hypertension in Hamadan city in 2024, from whom 384 participants were selected using purposive sampling. The research instruments included the Morisky Medication Adherence Scale (2008, MMAS), the NEO Five-Factor Inventory (Costa & McCrae, 1992, NEO-FFI), and the Intrinsic Motivation Inventory (McAuley et al., 1989, IMI). Data analysis was performed using simultaneous regression analysis. The results showed that the personality traits of neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness, as well as motivation, together explained 17% of the variance in treatment adherence (P<0.05). Based on these findings, it can be concluded that personality traits and motivation play an important role in predicting treatment adherence in patients with hypertension.
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