For many years scientists have tried hard and spent a lot of research budget in order to show the effect of medicine on brain , in the other hand our knowledge about how the psychotherapy works is nearly nothing. by considering the fact that psychotherapy has deep impression on emotion ,behavior and cognition it is expecting that it Influences the brains function and even its structure. nowdays by keeping distance of dualism , we confronting the huge amount of research about the effect of psychotherapy on brain. The National Institute of Mental Health in Research Domain Criteria has shifted their priorities to find out the physiologic mechanism of pathology and treatment of illness and spending budget for the purpose. in the same race, Neuroscience has developed and due to its Interdisciplinary nation it can be a good connection in order to achieve the goals. in this paper , considering the fact of brains flexibility , we take a look on researches in this area and we are looking for an answer for this questions:1) is psychotherapy has any effect on brains function and structure? 2) Are the psychotherapy and the medicine have the same effect on brain? 3) are the neurological and the physiological changes of psychotherapy can be an Objective tool in order to study the proceed and the results?
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